I find very poetic that the best support for Draco/Nero in this CQ is her uncle Caligula (which lets you skip the fight’s gimmick): with his support Draco is the easiest choice to SOLO this CQ, since she gets only the best parts from a fusion of a Berserker and a Ruler, on top of her super effective NP.
Kukulkan on the other hand can SOLO this CQ without help from the frontline, given the combination of spammable Skill Seal (again to delay/avoid the fight’s gimmick), super effective NP, amazing crit potential and good survival tools.
However you can’t just bring an hyper Kuku copy with the bonus damage gacha CE and blast the field, instead you must deal just enough damage to kill Sith & Galatea at the same time that you break Miss Crane (to avoid her NP Damage Resist until she is alone on the field): you’ll have to adapt the script to your own Kuku damage potential (NP level, Grails, CE used), by delaying your skills usage if your damage is to high (you use them one at a time instead of all at once to avoid dealing to much damage to Miss Crane) or by using Damage Bonus CCs on Kuku’s facacards (see TIPs in overlay during the video, her Quick & Arts are preferred) if your damage is too low